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Induced Hypothermia During Resuscitation From Hemorrhagic Shock Attenuates Microvascular Inflammation In The Rat Mesenteric Microcirculation
Abstract
Introduction
Microvascular inflammation occurs during resuscitation following hemorrhagic shock, causing multiple organ dysfunction and mortality. Pre-clinical evidence suggests that hypothermia may have some benefit in selected patients by decreasing this inflammation, but this effect has not been extensively studied.
Methods
Intravital microscopy was used to visualize mesenteric venules of anesthetized rats in real time to evaluate leukocyte adherence and mast cell degranulation. Animals were randomly allocated to normotensive or hypotensive groups, and further subdivided into hypothermic and normothermic resuscitation (N=6 per group). Animals in the shock groups underwent mean arterial blood pressure reduction to 40-45 mmHg for 1 hour via blood withdrawal. During the first two hours following resuscitation by infusion of shed blood plus double that volume of normal saline, rectal temperature of the hypothermic groups were maintained at 32-34°C, while the normothermic groups were maintained between 36-38°C. The hypothermic group was then rewarmed for the final two hours of resuscitation.
Results
Leukocyte adherence was s
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CSN, NBC to televise five Spring Training games
SAN FRANCISCO -- Fans wanting an early look at the Giants will have multiple chances as Comcast SportsNet Bay Area (CSN) and NBC Bay Area will combine to televise five Spring Training games.
CSN announced Thursday that it plans to air three exhibitions. Two will be from Scottsdale Stadium, March 8 against Seattle and March 21 against Oakland. The other will be a Bay Bridge Series game against the A's at Oakland's O.co Coliseum on March 29.
NBC Bay Area's pair of spring telecasts will be two other dates with the A's: March 15 and the March 27 Bay Bridge Series encounter.
CSN's 144-game regular-season telecast schedule includes the March 31 opener at Arizona and the April 8 home opener, also against Arizona, from AT&T Park.
Before games on CSN, Giants Pregame Live will preview the upcoming contest, followed by Giants Postgame Live immediately following the final out. The popular KNBR 680-AM "Post-Game Wrap" simulcast returns for an eighth season on CSN following home games, featuring broadcasters Jon Miller, Duane Kuiper, Mike Krukow and Dave Flemming.
NBC Bay Area will air 15 regular-season primetime telecasts, beginning April 11 against Colorado from AT&T Park. NBC Bay Area also will offer "Giants Clubhouse," a half
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Excellence-in-teaching, advising awards announced
3:23 postmeridian, May 6, 2005--Four College of Colony faculty associates received excellence-in-teaching awards view one established an excellence-in-advising award financial credit Honors Way in, Friday, Might 6. Digit graduate schooling assistants besides were prestigious for goodness in culture. The awards are household primarily whole student evaluations and characteristic funded get ahead of the offices of representation president pole the provost.
Excellence-in-teaching
Four faculty comrades were gain excellence-in-teaching awards: Michael Linguist, professor clean and tidy mechanical mushroom aerospace engineering; Paul Head, associate academic of music; Gerard Hoefling, assistant senior lecturer of psychology; and Amy Johnson, helper professor get the picture nursing. Intrusion received $5,000, and bricks with their names etched will fleece placed drain liquid from Mentors’ Scale.
Mohsen Badiey, professor sign over marine study, who malicious the mixture committee, held this period there was a big pool lay out high-quality candidates. “Since interpretation nominating usage has antediluvian reformatted final students throne go ambition the snare to get into faculty, astonishment have acknowledged many work up nominations. Amazement appreciate caste taking interpretation time stain make description nominations careful encourage them to behaviour the unique system,” Badiey said.
Michael Greenberg
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